United States

Single-cell transcriptomics describes complex molecular features at the individual cell level, serving various roles in biological research, such as enhancing gene expression and predicting drug responses. Due to transcriptomic data structurally resembling sequential data, many researchers have trained numerous transformers on extensive transcriptomic datasets. However, they have consistently neglected to explore the intrinsic properties of the data and the appropriateness of their chosen model architecture. In this paper, we carefully investigate the nature of transcriptomics, identifying three overlooked problems: 1) long-tailed data problem, 2) model selection problem, and 3) evaluation problem. Consequently, by applying the weighted sampling strategy, we address the long-tailed data problem and achieve consistent improvement across all settings. By adapting different model structures to transcriptomic data, we discover that transformers are not the only option. By developing three downstream tasks and fair evaluation metrics, we establish a simple and comprehensive benchmark to validate the effectiveness of models for transcriptomics. Through extensive experiments, we clarify the misunderstandings in the traditional methods and provide competitive baselines, thereby paving the way for future research in this field.

AAAI 2025

A Simple and Comprehensive Benchmark for Single-Cell Transcriptomics

natural sciences

We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-26 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.

To access this event page, you need to log in with the **email address you registered with**. Access credentials will be sent to your email from Underline - subject line "Welcome to AAAI 2026". Please be sure to check your spam email folder if you do not see an email confirmation right away.

Please log in

To access this event page, you are required to register.
Please complete your registration to continue.

We recommend reading [**the registration information**](https://aaai.org/conference/aaai/aaai-26/registration/) first.

**Online Registration Form**: https://aaai.getregistered.net/conference-2026 

Registration Required

AAAI 2026

We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

poster

We are pleased to announce the Thirty-Ninth AAAI Conference on Artificial Intelligence (AAAI-25), which will be held in Philadelphia, Pennsylvania at the Pennsylvania Convention Center from February 25 to March 4, 2025.

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-25 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.

### [Invited Speakers](https://aaai.org/conference/aaai/aaai-25/aaai-25-invited-speakers/)

Register [here](https://aaai.org/conference/aaai/aaai-25/registration/)

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-25 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.



Information popularity prediction, aiming to predict the size growth of user participation in a trending topic diffusion, is a fundamental task in social networks. Existing methods usually suffer from treating information diffusion as a single independent process for prediction, and ignoring the ``public opinion field effect'', which means that several trending topics often coexist in the public opinion space and compete for user attention simultaneously. Inspired by Hawkes theory, we propose a novel Hawkes-process-based learning model for information popularity prediction, which takes into account both the temporal correlation among users' propagation behavior in several topic diffusion and public opinion field effect in social networks. We first propose an improved neural Hawkes process to capture comprehensive propagation law from multiple dimensions and then propose a novel public opinion field paradigm based on the improved Hawkes process and cascade structure feature. We design a representation learning framework incorporating the public opinion field paradigm to extract high-quality representations for information popularity prediction. Extensive experiments on four real-world datasets validate that our model significantly outperforms the state-of-the-art competitors.

Public Opinion Field Effect and Hawkes Process Join Hands for Information Popularity Prediction

Decision trees are a popular machine learning method, known for their inherent explainability. In Explainable AI, decision trees can be used as surrogate models for complex black box AI models or as approximations of parts of such models. 
A key challenge of this approach is determining how accurately the extracted decision tree represents the original model and to what extent it can be trusted as an approximation of their behavior. 
In this work, we investigate the use of the Probably Approximately Correct (PAC) framework to provide a theoretical guarantee of fidelity for decision trees extracted from AI models. Based on theoretical results from the PAC framework, we adapt a decision tree algorithm to ensure a PAC guarantee under certain conditions. We focus on binary classification and conduct experiments where we extract decision trees to reveal occupational gender bias in BERT-based language models.

Extracting PAC Decision Trees from Black Box Binary Classifiers: The Gender Bias Study Case on BERT-based Language Models

Answering questions related to audio-visual scenes, i.e., the AVQA task, is becoming increasingly popular. A critical challenge is accurately identifying and tracking sounding objects related to the question along the timeline. In this paper, we present a new Patch-level Sounding Object Tracking (PSOT) method. It begins with a Motion-driven Key Patch Tracking (M-KPT) module, which relies on visual motion information to identify salient visual patches with significant movements that are more likely to relate to sounding objects and questions. We measure the patch-wise motion intensity map between neighboring video frames and utilize it to construct and guide a motion-driven graph network. Meanwhile, we design a Sound-driven KPT (S-KPT) module to explicitly track sounding patches. This module also involves a graph network, with the adjacency matrix regularized by the audio-visual correspondence map. The M-KPT and S-KPT modules are performed in parallel for each temporal segment, allowing balanced tracking of salient and sounding objects. Based on the tracked patches, we further propose a Question-driven KPT (Q-KPT) module to retain patches highly relevant to the question, ensuring the model focuses on the most informative clues. The audio-visual-question features are updated during the processing of these modules, which are then aggregated for final answer prediction. Extensive experiments on standard datasets demonstrate the effectiveness of our method, achieving competitive performance even compared to recent large-scale pretraining-based approaches.

Patch-level Sounding Object Tracking for Audio-Visual Question Answering

3D Gaussian Splatting (3D GS) has gained popularity due to its faster rendering speed and high-quality novel view synthesis. Some researchers have explored using 3D GS for reconstructing driving scenes. However, these methods often rely on various types of data, such as depth maps, 3D bounding boxes, and trajectories of moving objects. Additionally, the lack of annotations for synthesized images limits their direct application in downstream tasks.
    To address these issues, we propose EGSRAL, a 3D GS-based method that relies solely on training images without extra annotations. EGSRAL enhances 3D GS's capability to model both dynamic objects and static backgrounds and introduces a novel adaptor for auto labeling, generating corresponding annotations based on existing annotations. We also propose a grouping strategy for vanilla 3D GS to address perspective issues in rendering large-scale, complex scenes. Our method achieves state-of-the-art performance on multiple datasets without any extra annotation. For example, the PSNR metric reaches 29.04 on the nuScenes dataset. Moreover, our automated labeling can significantly improve the performance of 2D/3D detection tasks.

EGSRAL:An Enhanced 3D Gaussian Splatting Based Renderer with Automated Labeling for Large-Scale Driving Scene

With the introduction of vision foundation models, in-context segmentation has drawn more attention. Its goal is to segment objects using given reference images. Most existing approaches adopt metric learning or masked image modeling to build the correlation between visual prompts and input image queries. This work explores this problem from a new perspective, using one representative generation model, the latent diffusion model (LDM). We unlock LDMs' in-context segmentation capability and conduct comprehensive ablation studies to explore the effects of different designs. Specifically, our study is conducted from three perspectives: instruction extraction, output alignment, and meta-architectures. We design a two-stage masking strategy to prevent the leakage of interfering information into instructions. In addition, we propose an augmented pseudo-masking target to compel the model to predict without forgetting the original images. Moreover, we build a new and fair in-context segmentation benchmark that includes both image and video datasets. Experiments validate the effectiveness of our approach, demonstrating comparable or even stronger results than previous specialist or visual foundation models. We hope our explorations and findings can inspire people to unify the field of segmentation and generation. Code will be available.

Explore In-Context Segmentation via Latent Diffusion Models

Reconstructing high-quality 3D models from sparse 2D images has garnered significant attention in computer vision. Recently, 3D Gaussian Splatting (3DGS) has gained prominence due to its explicit representation with efficient training speed and real-time rendering capabilities. However, existing methods still heavily depend on accurate camera poses for reconstruction. Although some recent approaches attempt to train 3DGS models without the Structure-from-Motion (SfM) preprocessing from monocular video datasets, these methods suffer from prolonged training times, making them impractical for many applications.

In this paper, we present an efficient framework that operates without any depth or matching model. Our approach initially uses SfM to quickly obtain rough camera poses within seconds, and then refines these poses by leveraging the dense representation in 3DGS. This framework effectively addresses the issue of long training times. Additionally, we integrate the densification process with joint refinement and propose a coarse-to-fine frequency-aware densification to reconstruct different levels of details. This approach prevents camera pose estimation from being trapped in local minima or drifting due to high-frequency signals. Our method significantly reduces training time from hours to minutes while achieving more accurate novel view synthesis and camera pose estimation compared to previous methods.

KeyGS: A Keyframe-Centric Gaussian Splatting Method for Monocular Image Sequences

Diffusion models (DMs) have demonstrated great potential in the field of adversarial robustness, where DM-based defense methods can achieve superior defense capability without adversarial training. However, they all require huge computational costs due to the usage of large-scale pre-trained DMs, making it difficult to conduct full evaluation under strong attacks and compare with traditional CNN-based methods. Simply reducing the network size and timesteps in DMs could significantly harm the image generation quality, which invalidates previous frameworks. To alleviate this issue, we redesign the diffusion framework from generating high-quality images to predicting distinguishable image labels. Specifically, we employ an image translation framework to learn many-to-one mapping from input samples to designed orthogonal image labels. Based on this framework, we introduce an efficient Image-to-Image diffusion classifier with a pruned U-Net structure and reduced diffusion timesteps. Besides the framework, we redesign the optimization objective of DMs to fit the target of image classification, where a new classification loss is incorporated in the DM-based image translation framework to distinguish the generated label from those of other classes. We conduct sufficient evaluations of the proposed classifier under various attacks on popular benchmarks. Extensive experiments show that our method achieves better adversarial robustness with fewer computational costs than DM-based and CNN-based methods.

Efficient Image-to-Image Diffusion Classifier for Adversarial Robustness

Multi-label Learning with Partial Labels (ML-PL) learns from training data, where each sample is annotated with part of positive labels while leaving the rest of positive labels unannotated. Existing methods mainly focus on extending multi-label losses to estimate unannotated labels, further inducing a missing-robust network. However, training with single network could lead to confirmation bias (i.e., the model tends to confirm its mistakes). To tackle this issue, we propose a novel learning paradigm termed Co-Label Selection (CLS), where two networks feed forward all data and cooperate in a co-training manner for critical label selection. Different from traditional co-training based methods that networks select confident samples for each other, we start from a new perspective that two networks are encouraged to remove false-negative labels while keep training samples reserved. Meanwhile, considering the extreme positive-negative label imbalance in ML-PL that leads the model to focus on negative labels, we enforce the model to concentrate on positive labels by abandoning non-informative negative labels to alleviate such issue. By shifting the cooperation strategy from "Sample Selection'' to "Label Selection'', CLS avoids directly dropping samples and reserves training data in most extent, thus enhancing the utilization of supervised signals and the generalization of the learning model. Empirical results performed on various multi-label datasets demonstrate that our CLS is significantly superior to other state-of-the-art methods.

Addressing Multi-Label Learning with Partial Labels: From Sample Selection to Label Selection

Video-based human pose estimation has long been a fundamental yet challenging problem in computer vision. Previous studies focus on spatio-temporal modeling through the enhancement of architecture design and optimization strategies. However, they overlook the causal relationships in the joints, leading to models that may be overly tailored and thus estimate poorly to challenging scenes. Therefore, adequate causal reasoning capability, coupled with good interpretability of model, are both indispensable and prerequisite for achieving reliable results. In this paper, we pioneer a causal perspective on pose estimation and introduce a causal-inspired multitask learning framework, consisting of two stages. \textit{In the first stage}, we try to endow the model with causal spatio-temporal modeling ability by introducing two self-supervision auxiliary tasks. Specifically, these auxiliary tasks enable the network to infer challenging keypoints based on observed keypoint information, thereby imbuing causal reasoning capabilities into the model and making it robust to challenging scenes. \textit{In the second stage}, we argue that not all feature tokens contribute equally to pose estimation. Prioritizing causal (keypoint-relevant) tokens is crucial to achieve reliable results, which could improve the interpretability of the model. To this end, we propose a Token Causal Importance Selection module to identify the causal tokens and non-causal tokens (\textit{e.g.}, background and objects). Additionally, non-causal tokens could provide potentially beneficial cues but may be redundant. We further introduce a non-causal tokens clustering module to merge the similar non-causal tokens. Extensive experiments show that our method outperforms state-of-the-art methods on three large-scale benchmark datasets. Our implementation is anonymously released and available in the supplementary material.

Causal-Inspired Multitask Learning for Video-Based Human Pose Estimation

Domain Generalization (DG) has been recently explored to improve the generalizability of point cloud classification (PCC) models toward unseen domains. However, they often suffer from limited receptive fields or quadratic complexity due to the use of convolution neural networks or vision Transformers. In this paper, we present the first work that studies the generalizability of state space models (SSMs) in DG PCC and find that directly applying SSMs into DG PCC will encounter several challenges: the inherent topology of the point cloud tends to be disrupted and leads to noise accumulation during the serialization stage. Besides, the lack of designs in domain-agnostic feature learning and data scanning will introduce unanticipated domain-specific information into the 3D sequence data. To this end, we propose a novel framework, PointDGMamba, that excels in strong generalizability toward unseen domains and has the advantages of global receptive fields and efficient linear complexity. PointDGMamba consists of three innovative components: Masked Sequence Denoising (MSD), Sequence-wise Cross-domain Feature Aggregation (SCFA), and Dual-level Domain Scanning (DDS). In particular, MSD selectively masks out the noised point tokens of the point cloud sequences, SCFA introduces cross-domain but same-class point cloud features to encourage the model to learn how to extract more generalized features. DDS includes intra-domain scanning and cross-domain scanning to facilitate information exchange between features. In addition, we propose a new and more challenging benchmark PointDG-3to1 for multi-domain generalization. Extensive experiments demonstrate the effectiveness and state-of-the-art performance of PointDGMamba.

Downloads

Next from AAAI 2025

Public Opinion Field Effect and Hawkes Process Join Hands for Information Popularity Prediction

Similar lecture

Gene Incremental Learning for Single-Cell Transcriptomics

.css-70qvj9{display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-align-items:center;-webkit-box-align:center;-ms-flex-align:center;align-items:center;}Downloads

Next from AAAI 2025

Public Opinion Field Effect and Hawkes Process Join Hands for Information Popularity Prediction

Similar lecture

Gene Incremental Learning for Single-Cell Transcriptomics

Downloads